國立臺灣大學尖端生醫計算及影像研究中心

HIGHLIGHTS

112 HIGHTLIGHTS

113 HIGHTLIGHTS

114 HIGHTLIGHTS

115 HIGHTLIGHTS

112 HIGHTLIGHTS

Quantitative analysis of high‐throughput biological data

Hsueh-Fen Juan and Hsuan-Cheng Huang

BIC: a database for the transcriptional landscape of bacteria in cancer

Kai-Pu Chen, Chia-Lang Hsu, Yen-Jen Oyang, Hsuan-Cheng Huang and Hsueh-Fen Juan

MSIr: Automatic Registration Service for Mass Spectrometry Imag-ing and Histology

Bo-Jhang Lin, Tien-Chueh Kuo, Hsin-Hsiang Chung, Ying-Chen Huang, Ming-Yang Wang, Cheng-Chih Hsu, Po-Yang Yao and Yufeng Jane Tseng

Transcranial Burst Electrical Stimulation Contributes to Neuromodulatory Effects in the Rat Motor Cortex

Thi Xuan Dieu Nguyen, Chi-Wei Kuo, Chih-Wei Peng, Hao-Li Liu, Ming-Yuan Chang and Tsung-Hsun Hsieh

Pulsed Focused Ultrasound Reduces Hippocampal Volume Loss and Improves Behavioral Performance in the Kainic Acid Rat Model of Epilepsy

Po-Chun Chu, Chen-Syuan Huang, Shan-Zhi Ing, Hsiang-Yu Yu, Robert S Fisher and Hao-Li Liu

Stuck photoswitching event analysis and correction for superresolution single-molecule localization microscopy

Jiahui Wang, Jimmy Ching-Cheng Hsu, Ting-Jui Ben Chang, and T. Tony Yang

Single-molecule localization microscopy reveals the ultrastructural constitution of distal appendages in expanded mammalian centrioles

Ting-Jui Ben Chang, Jimmy Ching-Cheng Hsu and T. Tony Yang

Learning from Small Medical Data - Robust Semi-supervised Cancer Prognosis Classifier with Bayesian Variational Autoencoder

Te-Cheng Hsu and Che Lin

Ultra-low-dose 18F-PI-2620 Tau PET/MRI with Generative Adversarial Network-based Enhancement in Aging and Neurodegenerative Populations

Chen KT, Tesfay R, Koran MEI, Ouyang J, Shams S, Young CB, Davidzon GA, Liang T, Khalighi MM, Mormino E and Zaharchuk G

Nodal reactive proliferation of monocytoid B-cells may represent atypical memory B-cells

Shan-Chi Yu, Ko-Chen Chen and Ruby Yun-Ju Huang

Simple and Tighter Derivation of Achievability for Classical Communication Over Quantum Channels

Hao-Chung Cheng and Li Gao

Dopamine Activates the D1R-Zn2+ Signaling Pathway to Trigger Inflammatory Response in Primary-Cultured Rat Embryonic Cortical Neurons

Hui-Chiun Tseng and Chien-Yuan Pan

Long-term photobiomodulation of cellular and mitochondrial activities in IMR-32 cells using an 810 nm light-emitting diode

Huai-Ching Hsieh, Yi-Ju Lee, Kung-Bin Sung and An-Chi Wei

Complete genomic profiles of 1496 Taiwanese reveal curated medical insights

Jacob Shujui Hsu, Dung-Chi Wu, Shang-Hung Shih, Jen-Feng Liu, Ya-Chen Tsai, Tung-Lin Lee, Wei-An Chen, Yi-Hsuan Tseng, Yi-Chung Lo, Hong-Ye Lin, Yi-Chieh Chen, Jing-Yi Chen, Ting-Hsuan Chou, Darby Tien-Hao Chang, Ming Wei Su, Wei-Hong Guo, Hsin-Hsiang Mao, Chien-Yu Chen and Pei-Lung Chen

Single-cell multi-omic analysis reveals serum amyloid A3 restrains alternative activations in macrophages derived from different origins

Jian-Da Lin, Tzu-Yin Chou, Yu-Zhen Ye, I-Jung Lin, Chia-Jung Lien, Zhih-Yuan Wang, Chen-Hsuan Yang, Pei-An Chao, Yen-Ting Chen and P’ng Loke

Tumor-derived interleukin-1 receptor antagonist exhibits immunosuppressive functions and promotes pancreatic cancer

Yu-Ching Fan, Yu-Cin Fong, Chun-Tse Kuo, Chia-Wei Li, Wei-Yu Chen, Jian-Da Lin, Florian Bürtin, Michael Linnebacher, Quoc Thang Bui, Kuan-Der Lee and Yuan-Chin Tsai

113 HIGHTLIGHTS

NTU CACIB and U-Tokyo IQB MOU Signing Paves the Way for International Collaboration in Advanced Computing, AI and Imaging for Biomedical Research

https://www.cna.com.tw/postwrite/chi/373258

https://www.ntu.edu.tw/spotlight/2024/2283_20240703.html

Reflected-Shear-Wave Computed Tomography for Elasticity Imaging of 3D Cell Cultures Using a Single-Element

T.-W. Chen, Y.-C. Chen and P.-C. Li

Fourier-Based Fast 3-D Ultrasound Imaging Using Row–Column-Addressed 2-D Arrays

S.-C. Lin and P.-C. Li

FastEval Parkinsonism: An Instant Deep Learning–Assisted Video-Based Online System for Parkinsonian Motor Symptom Evaluation

YY Yang, MY Ho, CH Tai, RM Wu, MC Kuo*, YJ Tseng*

Pathological Gait Analysis with an Open-Source Cloud-Enabled Platform Empowered by Semi-Supervised Learning – PathoOpenGait

MY Ho, MC Kuo, CS Chen, RM Wu, CC Chuang, CS Shih, YJ Tseng*

Computer-aided diagnosis of Duchenne muscular dystrophy based on texture pattern recognition on ultrasound images using unsupervised clustering algorithms and deep learning

AH Liao, CH Wang, CY Wang, HL Liu, HC Chuang, WJ Tseng, CP Shih and PH Tsui

Neuromodulatory Responses Elicited by Intermittent Versus Continuous Transcranial Focused Ultrasound Stimulation of the Motor Cortex in Rats

TH Hsieh*, PC Chu, TXD Nguyen, CW Kuo,PK Chang, KHS Chen, HL Liu

Multiplexed Nanoscopy via Buffer Exchange

Ting-Jui Ben Chang and T. Tony Yang

Multimodal Attention Network for Dementia Prediction

Hsinhan Tsai, Ta-Wei Yang, Kai-Hao Ou, Tung-Hung Su, Che Lin and Cheng-Fu Chou

Exploiting Common Patterns in Diverse Cancer Types via Multi-Task Learning

B.-R. Wu, S. Ormazabal Arriagada, T.-C. Hsu, T.-W. Lin, and C. Lin

Dietary bacteria control fat content through pathways converging at phosphatidylcholine

eLife

Hsiao-Fen Han, Shao-Fu Nien, Hang-Shiang Jiang, Jui-Ching Wu, Chia-Yi Chiang, Man-Tzu Li, Leng-Jie Huang, Sufeng Chiang, Lien-Chieh Lin, Yi-Ting Chuang, Yu-Ho Lin, Chao-Wen Wang and Yi-Chun Wu

Early Frame Florbetaben PET/MRI for Cerebral Blood Flow Quantification in Patients with Cognitive Impairment: Comparison to an Oxygen-15 Water Gold Standard

Fettahoglu A, Zhao MY, Khalighi MM, Vossler H, Jovin M, Davidzon GA, Zeineh M, Boada F, Mormino E, Henderson V, Moseley M, Chen KT*, Zaharchuk G*

Regulating epithelial-mesenchymal plasticity from 3D genome organization

Pang QY, Chiu YC, Huang RY.

Robust Qubit Mapping Algorithm via Double-Source Optimal Routing on Large Quantum Circuits

Chin-Yi Cheng, Chien-Yi Yang, Yi-Hsiang Kuo, Ren-Chu Wang, Hao-Chung Cheng*, Chung-Yang (Ric) Huang

Metabolic regulation of mitochondrial morphologies in pancreatic beta cells: coupling of bioenergetics and mitochondrial dynamics

Wen-Wei Tseng, Ching-Hsiang Chu, Yi-Ju Lee, Shirui Zhao, Chen Chang, Yi-Ping Ho and An-Chi Wei

Trans-ancestry polygenic models for the prediction of LDL blood levels: an analysis of the United Kingdom Biobank and Taiwan Biobank

Emadeldin Hassanin, Ko-Han Lee, Tzung-Chien Hsieh, Rana Aldis, Yi-Lun Lee, Dheeraj Bobbili, Peter Krawitz, Patrick May, Chien-Yu Chen and Carlo Maj

TAG-SPARK: Empowering High-Speed Volumetric Imaging with Deep Learning and Spatial Redundancy

Y.-T. Hsieh, K.-C. Jhan, J.-C. Lee, G.-J. Huang, C.-L. Chung, W.-C. Chen, T.-C. Chang, B.-C. Chen, M.-K. Pan*, S.-C.

Existence of Pauli-like stabilizers for every quantum error-correcting code

Jhih-Yuan Kao* and Hsi-Sheng Goan*

Hamiltonian Phase Error in Resonantly Driven CNOT Gate Above the Fault-Tolerant Threshold

Y.-H. Wu*, L. C. Camenzind, A. Noiri, K. Takeda, T. Nakajima, T. Kobayashi, C.-Y. Chang, A. Sammak, G. Scappucci, H.-S. Goan, and S. Tarucha*

Assesing immune phenotypes using simple proxy measures: promise and limitations

AE Downie, RS Barre, A Robinson, J Yang, YH Chen, JD Lin, O Oyesola, F Yeung, K Cadwell, P Loke and AL Graham

Essential role of macrophages in contact hypersensitivity-induced hair regeneration

KR Huang, SMY Fan, KY Tai, JD Lin, CF Chang, KC Yang and SJ Lin

114 HIGHTLIGHTS

A computationally efficient FEM platform for comprehensive simulations of photoacoustic imaging

JR. Rahpeima, C.-H. Wen, and P.-C. Li

EMT and cancer: what clinicians should know

Erik W Thompson, Andrew D Redfern, Simone Brabletz, Geert Berx, Veenoo Agarwal, Karuna Ganesh, Ruby Y Huang, Dana Ishay-Ronen, Pierre Savagner, Guojun Sheng, Marc P Stemmler, Thomas Brabletz

Epithelial-mesenchymal transition

Cecilia Xi Zhang, Ruby Yun-Ju Huang, Guojun Sheng, and Jean Paul Thiery

DHODH Blockade Induces Ferroptosis in Neuroblastoma by Modulating the Mevalonate Pathway

Jui-Chia Shir, Pin-Yu Chen, Chuan-Hao Kuo, Chiao-Hui Hsieh, Hsin-Yi Chang, Hong-Chih Lee, Chen-Hao Huang, Chun-Hua Hsu, Wen-Ming Hsu, Hsuan-Cheng Huang, Hsueh-Fen Juan

Transcriptional dynamics of CD8+ T-cell exhaustion in immune checkpoint inhibitor resistance at single-cell resolution

Tzu-Yang Tseng, Ching-Hung Hsieh, Hsuan-Cheng Huang, Yu-Ching Wu, Chiun Hsu, Chia-Lang Hsu, Da-Liang Ou, Hsueh-Fen Juan

Multiphoton GRIN-Lens Microendoscopy for Living Brains

C.-S. Wang, X. Lai, P.-T. Yeh, P.-C. Liao, R. Kitamura, S.-K. Chen, Y. Liu, M. Cui, S.-W. Chu

Discrete photoentrainment of mammalian central clock is regulated by bi-stable dynamic network in the suprachiasmatic nucleus

P.-T. Yeh, K.-C. Jhan, E.-P. Chua, W.-C. Chen, S.-W. Chu, S.-C. Wu, S.-K. Chen

Nanophotonic inspection of deep-subwavelength integrated optoelectronic chips

Y. Che, T. Zhang, X. Liu, D. Hu, S. Song, Y. Cai, Y. Cao, J. Zhang, S.-W. Chu, and X. Li

Spontaneous upregulation of stemness and 3D spheroid formation of single cancer cells induced by scaffold-free polypeptide polyelectrolyte multilayer coating

Jia-Yang Chen, Chia-Chun Liu, Lucas Wang, Hang-Shiang Jiang, Pei Syuan Lu, Curtis W. Frank, Mark D. Pegram, Chun-Jen Huang, Yi-Chun Wu*, Chin-Lin Guo* and Ying-ChihChang

High Steatosis-Associated Fibrosis Estimator scores predict hepatocellular carcinoma in viral and non-viral hepatitis and metabolic dysfunction-associated steatotic liver disease

Su Tung-Hung,Yang Sheng-Shun,Lee Mei-Hsuan,Kao Wei-Yu,Huang Shang-Chin,Chen Fen-Fang,Poon Francis SK,Tsai Lung-Wen,Chen Yi-Ting,Lin Che,Wang Weichung,Kim W Ray,Kao Jia-Horng

Interpretable Independent Recurrent Networks for Forecasting Stroke in Atrial Fibrillation

Jung-Chi Hsu, Yi-Hsien Hsieh, Yen-Yun Yang, Shu-Lin Chuang, Che Lin, Lian-Yu Lin

SPARK Taiwan: a decade of insights in adapting US translational medicine and commercialization methods

Lo, T. F., Huang, Y. C., Cho, N. Y., Tseng, Y. J.

DeePFAS: Deep-Learning-Enabled Rapid Annotation of PFAS: Enhancing Nontargeted Screening through Spectral Encoding and Latent Space Analysis

Wang H., Kuo TC, Tseng, Y. J.

Advantages of two quantum programming platforms in quantum computing and quantum chemistry

Wang, P. H., Wu, W. Y., Lee, C. Y., Hong J. C., and Tseng, Y. J.

MRI-Styled PET: A Dual Modality Fusion Approach to PET Partial Volume Correction

Lin Y-N, Huang S-Y, Tsai C-H, Wang H-W, Chung M-C, Gong E, Hsiao I-T, Chen KT

Paired PET-MRI Deep Learning Model for Translating [11C]PiB to [18F]Florbetaben Amyloid Images

Tsai C-H, Huang S-Y, Wang H-W, Lin Y-N, Hsiao I-T, Chen KT

Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis

Chou, P.-C., Lin, Y.-H., Lin, I.-H., Lin, T.-Y., Huang, Y.-C., Hong, S.-R., Chang, T.-J. B., Fang, Y., Lin, Y., Yang, T. T., Lin, Y.-C., Huang, J.-R., Wang, W.-J.

Pushing Optical Resolution to the Few-Nanometer Scale via dSTORM Imaging of Expanded Specimen–Gel Composites

Hsu, J. C. C. and Yang, T. T.

Combination of skin sympathetic nerve activity and urine biomarkers in improving diagnostic accuracy for urge urinary incontinence

Yu-Chen Chen, Hao-Wei Chen, Tzu-Yu Liu, Yung-Shun Juan, Yu-Peng Liu, Shiou-Lan Chen, Chien-Hung Lee, Wei-Chung Tsai and Wen-Jeng Wu

Signatures of lower respiratory tract microbiome in children with severe community-acquired pneumonia using shotgun metagenomic sequencing

Ting-Yu Yen, Ching Hsu, Ni-Chung Lee, Chao-Szu Wu, Hsin Wang, Kuan-Yi Lee, Chia-Ray Lin, Chun-Yi Lu, Mo-Li Tsai, Tzu-Yu Liu, Che Lin, Chien-Yu Chen, Luan-Yin Chang, Feipei Lai, Li-Min Huang

Modulation of the immune response by focused ultrasound suppressed brain abscess formation

ZH Liu, NY Chen, CY Huang, YJ Lin, PK Yip, KC Wei, and HL Liu

Combination of Neuronavigation-Guided Focused Ultrasound and Bevacizumab for Patients With Recurrent Glioblastoma: A Pilot Study

KT Chen, HC Tsai, CY Huang, CT Liau, KC Ho, CH Toh, CC Chuang, PW Hsu, YC Huang, TW Chang, MC Yeap, PY Chen, CC Lee, YJ Lin, LY Feng, R Airan, G Li, M Lim, HL Liu*, KC Wei